Xin Wang
共找到 31 条论著文献

1、A Study of the Temperature Characteristics of Low Speed Curved Surface Jet in the Lower Air Supply Area

摘要:1 online resource Abstract: Semi-cylindrical diffusers are widely popular in displacement ventilation and lower air supply systems. The big point of the air flow characteristics of the curved surface jet is the "Cold Lake Effect", arounding the ground. In this paper, we derive a theoretical model of this "Cold Lake Effect" to investigate semi-cylindrical diffusers. The temperature distribution of the air supply in the main section was calculated with different air flow rate and initial air supply temperature. The temperature distribution model was experimentally verified. It is a good agreement with the calculated results, whereby the maximum deviation is 0.812°C. The study of the temperature characteristics, is a reference for making indoor thermal environment comfort better, and it can provide technical measures for designing air distribution systems in displacement ventilation and lower air supply systems.
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2、An overview of Sirtuins as potential therapeutic target: Structure, function and modulator

3、Query preserving graph compression 2012

摘要:p.157-168 It is common to find graphs with millions of nodes and billions of edges in, e.g. , social networks. Queries on such graphs are often prohibitively expensive. These motivate us to propose query preserving graph compression , to compress graphs relative to a class Λ of queries of users' choice. We compute a small G r from a graph G such that (a) for any query Q Ε Λ Q , Q ( G ) = Q'( G r ), where Q' Ε Λ can be efficiently computed from Q ; and (b) any algorithm for computing Q ( G ) can be directly applied to evaluating Q' on G r as is . That is, while we cannot lower the complexity of evaluating graph queries, we reduce data graphs while preserving the answers to all the queries in Λ. To verify the effectiveness of this approach, (1) we develop compression strategies for two classes of queries: reachability and graph pattern queries via (bounded) simulation. We show that graphs can be efficiently compressed via a reachability equivalence relation and graph bisimulation, respectively, while reserving query answers. (2) We provide techniques for aintaining compressed graph G r in response to changes Δ G to the original graph G . We show that the incremental maintenance problems are unbounded for the two lasses of queries, i.e. , their costs are not a function of the size of Δ G and changes in G r . Nevertheless, we develop incremental algorithms that depend only on Δ G and G r , independent of G , i.e., we do not have to decompress G r to propagate the changes. (3) Using real-life data, we experimentally verify that our compression techniques could reduce graphs in average by 95% for reachability and 57% for graph pattern matching, and that our incremental maintenance algorithms are efficient.
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4、Optimized transport properties of GaN MISHEMTs with thin AlN interlayer

摘要:The high electron mobility and carrier density induced by the AlGaN and GaN heterojunction has exhibited great promise for high frequency and high-power applications and has attracted numerous research efforts [1]. The AlGaN/GaN high electron mobility transistors (HEMT) with a traditional Schottky metal gate suffer from large gate leakage at positive biases, and as a result, MISHEMTs with an insulating layer of high-k dielectrics is usually adopted for improved interface and leakage properties [2,3]. Moreover, previous studies show that improved output performance and reliability properties can be realized by inserting a thin AlN in between the AlGaN and GaN heterojunction [4]. In this work, detailed studies of capacitance-voltage (CV), output current, interface properties, and breakdown voltage have been carried out, and by optimizing the interface properties from both high-κ dielectrics and the AlN layer, improved transport properties can be achieved for GaN MISHEMTs.
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5、Improved Interface Properties and Dielectric Breakdown in Recessed AlGaN/GaN MOS-HEMTs Using HfSiOx as Gate Dielectric

摘要:In this letter, we report optimized transport properties in gate recessed enhancement-mode GaN MOS-HEMTs by incorporating silicon into atomic layer deposited gate dielectric HfO2. Compared with commonly used HfO2 gate dielectric, the interface trap density can be reduced by nearly an order of magnitude and the fixed oxide traps inside reduces to almost half using the high quality passivation of HfSiOx. The MOS-HEMTs based on HfSiOx exhibit a threshold voltage of 1.5 V, excellent subthreshold swing of 65 mV/dec, a high on-off ratio of 3×1010. The incorporation of silicon in HfO2 can also increase dielectric breakdown property with maximum gate electric field of 2.85 MV/cm for 10-year time-dependent gate dielectric breakdown lifetime, which is 36 % higher than pure HfO2. The maximum breakdown voltage of HfSiOx MOS-HEMT is 742 V, which is 30% higher than HfO2 MOS-HEMT.
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6、Differential diagnosis of eccrine spiradenoma: A case report

摘要:Eccrine spiradenoma (ES) is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. A 44‑year‑old male with a blue-colored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Dermatological examination was undertaken, followed by surgical excision of the subcutaneous lesion and histopathological examination of the tissue. Subjective symptoms included tenderness upon palpation and routine investigations were within normal limits. Immunohistochemical analysis of the tumor cells demonstrated positive staining for CK5/CK6, CK8/CK18, S100, as well as small vacuole-like positive for EMA, and was therefore diagnosed as ES. The results of the present study suggest that immunohistochemical assays may be helpful to clarify the diagnosis and differentiate ES from other painful subcutaneous tumors exhibiting similar clinical and histological presentations.
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7、Capital Markets in China and Britain, 18th and 19th Century Evidence from Grain Price 2015

摘要:從書:Working paper series, 21349 Based on the most comprehensive grain prices available, we employ an asset-pricing model to estimate consistent interest rates and compare capital market development in Britain and China. Estimated interest rates for Britain were at least 28% lower than for China from 1770 to 1860. Regional capital market integration in the Yangzi Delta comes close to the British average at distances below 200 kilometers, but at larger distances interest rate correlations in Britain are twice those of the Delta, and three or more times as high as elsewhere in China. Overall, our results suggest capital market divergence at an early date.
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8、Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid

摘要:Human papillomavirus (HPV) type 16 is the most common type implicated as the etiological agent that causes cervical cancer. The marketed prophylactic vaccines against HPV infection are composed of virus-like particles (VLPs) assembled from the recombinant major capsid protein L1. Elicitation of functional and neutralizing antibodies by vaccination is the mode of action by which the vaccines prevent the viral infection. In this study, a panel of murine mAbs against HPV16 L1 were generated and comprehensively characterized with respect to their mapping to the epitope spectrum on the viral capsid. These mAbs were categorized into five epitope bins by two different methods based on the pairwise cross-inhibition and competition with human polyclonal antibodies. In addition, a preliminary demonstration of the spatial relationship of the epitopes recognized by these mAbs was performed using a cross-blocking assay with a well-characterized human mAb, 26D1. Interestingly, two mAbs recognizing different epitopes were found to act synergistically in the pseudovirion-based neutralization assay (PBNA). To facilitate cross-lab and cross-study comparison, the international standard (IS) serum 05/134 was used to calibrate the mAbs as well as the human serum samples from the HPV16/18 vaccine recipients. The neutralizing mAbs, particularly those that recognizing immunodominant epitopes, would be useful in developing epitope-specific assays for monitoring the vaccine production process and for serological assessment.
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9、Incremental graph pattern matching

摘要:Graph pattern matching is commonly used in a variety of emerging applications such as social network analysis. These applications highlight the need for studying the following two issues. First, graph pattern matching is traditionally defined in terms of subgraph isomorphism or graph simulation. These notions, however, often impose too strong a topological constraint on graphs to identify meaningful matches. Second, in practice a graph is typically large, and is frequently updated with small changes. It is often prohibitively expensive to recompute matches starting from scratch via batch algorithms when the graph is updated. This article studies these two issues. (1) We propose to define graph pattern matching based on a notion of bounded simulation, which extends graph simulation by specifying the connectivity of nodes in a graph within a predefined number of hops. We show that bounded simulation is able to find sensible matches that the traditional matching notions fail to catch. We also show that matching via bounded simulation is in cubic time, by giving such an algorithm. (2) We provide an account of results on incremental graph pattern matching, for matching defined with graph simulation, bounded simulation, and subgraph isomorphism. We show that the incremental matching problem is unbounded, that is, its cost is not determined alone by the size of the changes in the input and output, for all these matching notions. Nonetheless, when matching is defined in terms of simulation or bounded simulation, incremental matching is semibounded, that is, its worst-time complexity is bounded by a polynomial in the size of the changes in the input, output, and auxiliary information that is necessarily maintained to reuse previous computation, and the size of graph patterns. We also develop incremental matching algorithms for graph simulation and bounded simulation, by minimizing unnecessary recomputation. In contrast, matching based on subgraph isomorphism is neither bounded nor semibounded. (3) We experimentally verify the effectiveness and efficiency of these algorithms, and show that: (a) the revised notion of graph pattern matching allows us to identify communities commonly found in real-life networks, and (b) the incremental algorithms substantially outperform their batch counterparts in response to small changes. These suggest a promising framework for real-life graph pattern matching.
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10、Pathway into the silicon nucleation on silicene substrate at nanoscale

摘要:The solidification process of silicon atoms on the heterogeneous surface of silicene in different shapes, ranging from plane, curved to tubular substrates, is studied by means of molecular dynamics (MD) simulations. The shape of nucleus determines the stacking sequence of silicon atoms. Silicene plate induces strong ordered liquid layers while the silicene nanotube (SNT) makes the silicon imprint its cylindrical structure. In the confined nanospace between SNTs, the growth competition has been observed, which causes structural changes at the shared interface. The internal potential field around SNT is responsible for the formation of spiral structures and the growth competition. The ordering degree decays with increasing distances from the SNT, which is the result of the decreasing acting force from nucleus. This study provides an opportunity for comprehensive and satisfactory understanding of the heterogeneous nucleation at nanoscale.Display Omitted• Adding silicene nanotube (SNT) into silicon melt forms spiral atomic chains. • These silicon helical nanostructures show structural relevance with SNT. • The SNT-induced mechanism influences the epitaxial growth of silicon. • The field around SNT is responsible for the formation of nanostructures. • This study allows us to see the growth pattern of silicon induced by silicene.
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11、Overexpression of ShDHN, a dehydrin gene from Solanum habrochaites enhances tolerance to multiple abiotic stresses in tomato 2015

摘要:1 online resource Highlights: ShDHN expression was induced by abiotic stresses and exogenous signaling molecules. Overexpression of ShDHN enhanced tolerance to multiple abiotic stresses in tomato. Transgenic plants exhibited higher ROS scavenging ability under stress conditions. Transgenic plants had better water-retention capacity under dehydration conditions. Transgenic plants showed altered expression of antioxidant and JA-responsive genes. Abstract: Dehydrins (DHNs) play important roles in plant adaptation to abiotic stress. In this study, a cold-induced SK3-type DHN gene ( ShDHN ) isolated from wild tomato species Solanum habrochaites was characterized for its function in abiotic stress tolerance. ShDHN was constitutively expressed in root, leaf, stem, flower and fruit. ShDHN was continuously up-regulated during cold stress and showed higher expression level in the cold-tolerant S. habrochaites than in the susceptible S. lycopersicum . Moreover, ShDHN expression was also regulated by drought, salt, osmotic stress, and exogenous signaling molecules. Overexpression of ShDHN in cultivated tomato increased tolerance to cold and drought stresses and improved seedling growth under salt and osmotic stresses. Compared with the wild-type, the transgenic plants accumulated more proline, maintained higher enzymatic activities of superoxide dismutase and catalase, and suffered less membrane damage under cold and drought stresses. Moreover, the transgenic plants accumulated lower levels of H2 O2 and O2 − under cold stress, and had higher relative water contents and lower water loss rates under dehydration conditions. Furthermore, overexpression of ShDHN in tomato led to the up- or down-regulated expression of several genes involved in ROS scavenging and JA signaling pathway, including SOD1, GST, POD, LOX, PR1 and PR2. Taken together, these results indicate that ShDHN has pleiotropic effects on improving plant adaptation to abiotic stresses and that it possesses potential usefulness in genetic improvement of stress tolerance in tomato.
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12、Systems and computer technology : proceedings of the 2014 International Symposium and Computer Technology (ISSCT 2014), Shanghai, China, 15-17 November 2014 2015

13、Calcium phosphate nanoparticles as a new generation vaccine adjuvant

14、CAPITAL MARKETS IN CHINA AND BRITAIN, 18TH AND 19TH CENTURY: EVIDENCE FROM GRAIN PRICES

15、Unraveling the concentration-dependent metabolic response of Pseudomonas sp. HF-1 to nicotine stress by 1H NMR-based metabolomic

16、Novel bile acid sequestrant: A biodegradable hydrogel based on amphiphilic allylamine copolymer

摘要:Amphiphilic copolymer P(AH-co-AHH) was synthesized by aqueous solution copolymerization of allylamine hydrochloride (AH) with allylhexylamine hydrochloride (AHH). The double Schiff-base cross-linked hydrogel, which could be used as a biodegradable bile acid sequestrant was prepared using P(AH-co-AHH) and the double aldehyde cross-linker (OG) obtained by the oxidation of methyl α-d-glucopyranoside by sodium periodate. The properties of the P(AH-co-AHH)/OG hydrogel material including the gelation mechanism, rheological research, SEM observations, swelling characteristics, and the in vitro biodegradability were systematically studied. The binding mechanism between sodium glycocholate (NaGC) and the P(AH-co-AHH) precursor was confirmed as an synergetic effect of electrostatic interactions and hydrophobic associations, which were investigated by isothermal titration calorimetry (ITC). Moreover, the hydrogel showed high equilibrium adsorption capacity towards NaGC within only 2h and the adsorption kinetics and isotherms fit the pseudo-second-order model and Langmuir model, respectively. According to our experimental results, the hydrogel materials showed great potential to break the enterohepatic circulation of bile acid salts and could be further used for treating hypercholesterolemia.
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17、Status and Perspectives of Clinical Modes in Surgical Patients With Lung Cancer 2016

摘要:1 online resource Abstract : Abstract: To investigate the association between the clinical characteristics and clinical modes of surgically treated lung cancer patients, we conducted a retrospective study with 1097 lung cancer patients receiving pulmonary resection between 2012 and 2013. A physical examination or screening (PES) group (n = 267) and a symptomatic (SY) group (n = 830) were established depending on the new clinical mode (sequence of physical examination, early detection and sequential medical treatment) and the conventional mode (hospitalization due to occurrence of relevant symptoms), respectively. A higher proportion of patients referred to our unit directly form a junior medical unit is found in PES group (43.8%, 117/267 vs 13.6%, 113/830) ( P  < 0.001) and 37.5% (100/267) patients in PES group spent <1 months from detection or first medical visit to diagnosis compared with 15.4% (128/830) patient in SY group ( P  < 0.001). A significantly higher proportion of PES patients versus SY patients received video-assisted thoracoscopic surgery (VATS) resection (67.8%, 183/267 vs 42.6%, 352/830; P  < 0.001). A significantly higher proportion of PES patients versus SY patients chose sublobar resection (16.9%, 45/267 vs 7.6%, 63/830; P  < 0.001). A significantly higher proportion of PES patients versus SY patients are at stage 0 or I (64.4%, 172/267 vs 40.7%, 338/830; P  < 0.000). The postoperative incidence rate of complications in 30 days is significantly higher in SY group than in PES group (34.9% vs 27.3%; P  = 0.022). Helping to early diagnosis and surgical treatment, early tumor detection via PES may contribute to significantly higher proportions of early-stage lung cancer, use of VATS pulmonary resection, and sublobectomy as well as lower complication rate.
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18、A rare case of primary peripheral epithelial myoepithelial carcinoma of lung 2016

摘要:1 online resource Abstract: Background: Primary salivary gland–type tumors of lung are rare. Epithelial–myoepithelial carcinoma (EMC) of the lung is a minor salivary gland–type tumor subtype. Methods: We report a very rare case of EMC located in the peripheral left lower lobe that was diagnosed in a 58-year-old man and this is the first study in which we summarize all the patients with primary peripheral lung EMC concerned with the clinical features. Informed consent was obtained from the patient. Results: Chest computed tomography displayed an anomalous soft tissue mass with slightly lobular borders in the peripheral segment of the left lower lobe and closed to the visceral pleura. The surgery was performed by using video-assisted thoracic surgery. Grossly, the tumor was solitary, well-circumscribed, and unencapsulated endobronchial lesion. A microscopic examination revealed that it was circumscribed, although the tumor borders may show single cells or clusters of cells proliferating away from the main tumor mass. The inner tubular layer showed epithelial cell characteristics, whereas the outer layer exhibited myoepithelial cell characteristics. Immunostaining for P40, P63, and cytokeratin 5/6 was positive. However, the anaplastic lymphoma kinase-V, thyroid transcription factor-1, synaptophysin, chromogranin A and napsin A were negative. Conclusions: Literature review showed that most of patients with peripheral EMC were asymptomatic. Computed tomography and magnetic resonance imaging scans are able to indicate the presence of peripheral EMC. Pathological analysis is an effective method to clarify the diagnosis. Surgery is a regular treatment method. To facilitate the preoperative diagnosis and avoid the misdiagnosis of such a rare disease, more cases will need to be reported.
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19、The significance of nuclear factor-kappa B signaling pathway in glioma: A review

20、Trim9 Regulates Activity-Dependent Fine-Scale Topography in Drosophila

摘要:Topographic projection of afferent terminals into 2D maps in the CNS is a general strategy used by the nervous system to encode the locations of sensory stimuli. In vertebrates, it is known that although guidance cues are critical for establishing a coarse topographic map, neural activity directs fine-scale topography between adjacent afferent terminals [1-4]. However, the molecular mechanism underlying activity-dependent regulation of fine-scale topography is poorly understood. Molecular analysis of the spatial relationship between adjacent afferent terminals requires reliable localization of the presynaptic terminals of single neurons as well as genetic manipulations with single-cell resolution in vivo. Although both requirements can potentially be met in Drosophila melanogaster [5, 6], no activity-dependent topographic system has been identified in flies [7]. Here we report a topographic system that is shaped by neuronal activity in Drosophila. With this system, we found that topographic separation of the presynaptic terminals of adjacent nociceptive neurons requires different levels of Trim9, an evolutionarily conserved signaling molecule [8-11]. Neural activity regulates Trim9 protein levels to direct fine-scale topography of sensory afferents. This study offers both a novel mechanism by which neural activity directs fine-scale topography of axon terminals and a new system to study this process at single-neuron resolution.• Nociceptive afferents in Drosophila larva form fine-scale topography • Neural activity regulates larval nociceptive topography • Trim9 directs the fine-scale topography of larval nociceptive afferents • Neural activity regulates Trim9 expression to direct fine-scale topographyThe segregation of presynaptic terminals of same-type neurons is important for topographic projections of sensory afferents. Yang et al. report that nociceptive afferents in Drosophila larva form fine-scale topography. In this system, neural activity regulates Trim9 protein levels to direct fine-scale topography.
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