Furong Gao
共找到 4 条论著文献

1、Control and Profile Setting of Reactive Distillation Column for Benzene Chloride Consecutive Reaction System

2、Design of fuzzy iterative learning fault-tolerant control for batch processes with time-varying delay

摘要:In this paper, a new two-dimensional (2D) fuzzy composite iterative learning fault-tolerant control strategy using a 2D Takagi-Sugeno fuzzy model is proposed for batch processes with time delay and actuator faults. Firstly, based on the local-sector nonlinearity method, a 2D Takagi-Sugeno fuzzy model representing the nonlinear batch process with actuator faults is constructed with a series of linear models and nonlinear membership functions. Then, a 2D fuzzy feedback control-based iterative learning fault-tolerant control strategy is proposed under the constructed model. Using the 2D Lyapunov stability theory, sufficient conditions for system asymptotic stability are given. The fault-tolerant control law is then designed, guaranteeing system asymptotic stability along time and batches even if the system fails. Finally, the traditional control algorithm, the pure iterative learning control algorithm, and the feedback control-based iterative learning control algorithm proposed in this paper are compared on the level control of the three-tank system, which proves the effectiveness of the proposed method.
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3、Step Response Identification under Inherent-Type Load Disturbance with Application to Injection Molding

4、OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Model

摘要:Ofd1 is a newly identified causative gene for Retinitis pigmentosa (RP), a photoreceptor degenerative disease. This study aimed to examine Ofd1 localization in retina and further to investigate its function in photoreceptor degeneration models. Ofd1 localization in rat retina was examined using immunofluorescence. N-methyl-N-nitrosourea (MNU)-induced rats and Royal College of Surgeons (RCS) rats were used as photoreceptor degeneration models. The expression pattern of Ofd1, other ciliary associated genes and Wnt signaling pathway genes were examined in rat models. Furthermore, pEGFP-Ofd1-CDS and pSUPER-Ofd1-shRNA were constructed to overexpress and knockdown the expression level in 661W and R28 cells. MNU was also used to induce cell death. Cilia formation was observed using immunocytochemistry (ICC). Reactive oxygen species (ROS) were detected using the 2', 7'-Dichlorofluorescin diacetate (DCFH-DA) assay. Apoptosis genes expression was examined using qRT-PCR, Western blotting and fluorescence-activated cell sorting (FACS). Ofd1 localized to outer segments of rat retina photoreceptors. Ofd1 and other ciliary proteins expression levels increased from the 1st and 4th postnatal weeks and decreased until the 6th week in the RCS rats, while their expression consistently decreased from the 1st and 7th day in the MNU rats. Moreover, Wnt signaling pathway proteins expression was significantly up-regulated in both rat models. Knockdown of Ofd1 expression resulted in a smaller population, shorter length of cell cilia, and lower cell viability. Ofd1 overexpression partially attenuated MNU toxic effects by reducing ROS levels and mitigating apoptosis. To the best of our knowledge, this is the first study demonstrating Ofd1 localization and its function in rat retina and in retinal degeneration rat models. Ofd1 plays a role in controlling photoreceptor cilium length and number. Importantly, it demonstrates a neuroprotective function by protecting the photoreceptor from oxidative stress and apoptosis. These data have expanded our understanding of Ofd1 function beyond cilia, and we concluded that ofd1 neuroprotection could be a potential treatment strategy in retina degeneration models.
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