Jia Xu
共找到 4 条论著文献

1、Effect of coagulation bath conditions on the morphology and performance of PSf membrane blended with a capsaicin-mimic copolymer

摘要:In this study, asymmetric polysulfone (PSf) membranes with capsaicin-mimic groups were prepared from PSf/P(H-M)/DMAc system via phase inversion induced by immersion precipitation. Effects of coagulation bath temperature and composition on morphology, wettability, pure water permeability (L
展开
选择 引用 收藏

2、Communication -- The human D1261 mutation of the HERG potassium channel res lts in a truncated protein that contains a subunit interaction domain and

3、Preparation and characterization of a novel polysulfone UF membrane using a copolymer with capsaicin-mimic moieties for improved anti-fouling propertie

摘要:This work reports a novel polysulfone (PSf) membrane blended with a ternary copolymer having capsaicin-mimic moieties as an anti-fouling and anti-bacterial agent. This copolymer, P(H-M-A), was synthesized from N-(4-hydroxy-3-methoxy benzyl) acrylamide (HMBA), methyl methacrylate (MMA) and acrylic acid (AAc) by free radical polymerization. The effects of the P(H-M-A) content in the membrane casting solution on the structure and ultrafiltration performance of the membrane were investigated. It was shown that incorporating a small quantity of P(H-M-A) into the membrane improved the permeate flux and rejection when tested with a model humic acid (HA) solution and actual raw seawater. The P(H-M-A)-containing membranes exhibited excellent anti-bacterial activity, which was attributed to the capsaicin-mimic moieties, and their anti-fouling characteristics were demonstrated with fouling and cleaning experiments. This work suggests that P(H-M-A) is a potential hydrophilic anti-fouling and anti-bacterial agent for use in membranes for water applications.• Hydrophilicity of the membrane surface was enhanced. • Yielded a better separation performance. • Exhibited good anti-bacterial and anti-organic fouling activity. • Easier to clean in removing the foulants. • An interesting anti-fouling agent in membranes for water treatment.
展开
选择 引用 收藏

4、Nitidine chloride inhibits proliferation, induces apoptosis via the Akt pathway and exhibits a synergistic effect with doxorubicin in ovarian cancer cell

摘要:Nitidine chloride (NC) exhibits anti-tumor properties in various types of tumor. However, to the best of our knowledge there is no previous evidence of NC involvement in the apoptosis or proliferation of ovarian cancer cells and the underlying molecular mechanisms. The present study aimed to investigate the influence of NC on the viability and apoptosis of ovarian cancer cells and the synergistic effect NC and doxorubicin (DOX) may have on ovarian cancer cells. The viability and proliferation of ovarian cancer cells were examined using a methyl thiazolyl tetrazolium assay and 3H-thymidine incorporation assay. The apoptotic rate of ovarian cancer cells was detected by flow cytometry. The expression of apoptosis???associated proteins and Akt serine/threonine kinase??1 (Akt) were determined by western blot analysis following NC treatment. The inhibitory effect of NC on the proliferation of ovarian cancer cells was demonstrated in a time and dose???dependent manner. The pro-apoptotic effect of NC on ovarian cancer cells was also observed. It was determined that NC significantly downregulated the protein expression levels of B???cell CLL/lymphoma 2 (Bcl-2) and upregulated the expression of Bcl???2???associated X protein, p53, caspase???3 and ???9. NC suppressed Akt phosphorylation. Additionally, the present study demonstrated that the effect of NC on the proliferation and apoptosis of ovarian cancer cells was Akt???dependent by using the phosphatidylinositol-4,5-bisphosphate??3-kinase/Akt signaling pathway inhibitor, LY294002. NC exhibited a synergistic inhibitory effect on the viability of ovarian cancer cells when combined with DOX. The current study demonstrated that NC inhibited the proliferation and induced the apoptosis of ovarian cancer cells via the Akt signaling pathway and highlighted its potential clinical application for the treatment of ovarian cancer.
展开
选择 引用 收藏