Jun Liu
共找到 31 条论著文献

1、Preparation and RGB upconversion optic properties of transparent anti-counterfeiting films1 2017

摘要:1 online resource Abstract : A series of anti-counterfeiting labels based on RGB upconversion inks was designed for the die-cutting packages, suggesting a highly advanced security effect for the package anti-counterfeiting application. Abstract : Advanced anti-counterfeiting labels have aroused an intensive interest in packaging industry to avoid the serious issue of counterfeit. However, the preparation and cost of the existing labels associated with the drawbacks, including the complex and high-cost equipment, limit the protection of the authenticity of goods. Herein, we developed a series of anti-counterfeiting labels based on multicolor upconversion micro-particles (UCMPs) inks via straightforward and low-cost solutions, including spin-coating, stamping and screen printing. The UCMPs were synthesized through a facile hydrothermal process and displayed tunable red (R), green (G) and blue (B) color by doping different lanthanide ions, which are Er 3+ /Tm 3+, Yb 3+ /Er 3+ and Yb 3+ /Tm 3+ in NaYF4 hosts, respectively. The optimal UCMPs inks were deposited on a flexible polyethylene terephthalate (PET) substrate to obtain transparent anti-counterfeiting labels possessing higher transmittance, stronger upconversion fluorescence intensity and good photostability. Under ambient conditions, the patterns and films were transparent, but could exhibit multicolor light under 980 nm laser excitation. They can be used as anti-counterfeiting labels for die-cutting packages to further elevate the security of goods. The tunable and designable transparent anti-counterfeiting labels based on RGB UCMPs inks exhibit the merits of low-cost, easy-manufacture and versatility, underlying the practical application in the field of anti-counterfeiting.
展开
选择 引用 收藏

2、Enabling High-Energy-Density Cathode for Lithium–Sulfur Batterie

3、From ZnSn(OH)6 to SnS2: Topotactic transformation synthesis of SnS2 hierarchical microcubes with superior Li-ion storage performance

摘要:Display Omitted• Uniform 3D hierarchical SnS2 microcubes were synthesized via a topotactic transformation route. • The anode of these 3D SnS2 microcubes exhibited stable cycling performance. • The anode of these 3D SnS2 microcubes also showed superior rate capability.The 3D hierarchical microstructured electrodes by assembling the individual 1D/2D nanosubunits can fully take advantage of the merit of 1D/2D nanostructured materials, as well as alleviate their drawbacks. In this work, SnS2 3D hierarchical microcubes consisting of 2D nanosheet subunits were facilely synthesized via a simple topotactic transformation with room-temperature coprecipitated ZnSn(OH)6 microcubes as the template. Compared to bulk counterparts, this microstructured SnS2 was found to have a unique morphology and electrochemical interfacial regions that facilitated highly efficient Li-ion insertion/extraction and effectively accommodate the large volume changes during charge/discharge cycles. Over the whole 200 cycles at 1C current density, an outstanding cycleing stability is exhibited, with a high stable specific capacity of about 640 mA h g−1.
展开
选择 引用 收藏

4、Novel inlet-airframe integration methodology for hypersonic waverider vehicle

摘要:With the aim of integrating a ramjet or scramjet with an airframe, a novel inlet-airframe integration methodology for the hypersonic waverider vehicle is proposed. For this newly proposed design concept and for the specified flight conditions, not only the forebody of the vehicle but also its engine cowl and wings can ride on the bow shock wave, causing the bow shock wave to remain attached to the leading edge for the entire length of the vehicle. Thus, this integrated vehicle can take full advantage of the waverider׳s high lift-to-drag ratio characteristics and the ideal pre-compression surface for the engine. In this work, a novel inlet-airframe integrated axisymmetric basic flow model that accounts for both external and internal flows is first designed using the method of characteristics and the streamline tracing technique. Subsequently, the design of the inlet-airframe integrated waverider vehicle is generated from the integrated axisymmetric basic flow model using the streamline tracing technique. Then, the design methodologies of both the integrated axisymmetric basic flow model and the integrated waverider vehicle are verified by a computational numerical method. Finally, the viscous effects and performance of both the integrated axisymmetric basic flow model and the integrated waverider vehicle are analysed under the design condition using the numerical computation. The obtained results show that the proposed approach is effective in designing the integrated hypersonic waverider vehicle.
展开
选择 引用 收藏

5、A novel role for thyroid-stimulating hormone: Up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protei

摘要:Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that in liver cells, TSH promoted the expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR), a rate-limiting enzyme in cholesterol synthesis, by acting on the TSH receptor in hepatocyte membranes and stimulating the cyclic adenosine monophosphate / protein kinase A / cyclic adenosine monophosphate-responsive element binding protein (cAMP/PKA/CREB) signaling system. In thyroidectomized rats, the production of endogenous thyroid hormone was eliminated and endogenous TSH was suppressed through pituitary suppression with constant administration of exogenous thyroid hormone, and hepatic HMGCR expression was increased by administration of exogenous TSH. These results suggested that TSH could up-regulate hepatic HMGCR expression, which indicated a potential mechanism for hypercholesterolemia involving direct action of TSH on the liver. (HEPATOLOGY 2010)
展开
选择 引用 收藏

6、Dose-dependent target diversion of Danhong injection on the Glu-GLT-1/Gly-GlyRα dynamic balance module of cerebral ischemia

摘要:Function-oriented modular structure analysis is a great challenge in module-based pharmacological studies. A strategy to uncover target-target interaction (TTI) and dynamic balance regularity (DBR) was established to discover the structural factors influencing modular functions and explore the mechanism of Danhong injection (DHI) in treating cerebral ischemia. The dose-related metabolic features of DHI intervention were investigated using metabolomics and modular pharmacology. The findings indicated that Glu/Gly was a biomarker and Glu-GLT-1/Gly-GlyRα was the core unit regulated by DHI. Gly and Glu displayed opposite patterns and functional roles, representing intra-modular balance. GlyRα was identified as the upstream target and GLT-1 as the downstream target by inhibiting or activating GlyRα, indicating that DHI has two dose-dependent regulatory modes. GlyRα was the major target at low doses, while GLT-1 was activated as the dominant target as doses accumulated. Our study reveals that target-target interaction and dynamic balance regularity are the key factors influencing modular functions, which is a promising breakthrough for module-based pharmacological studies.
展开
选择 引用 收藏

7、Self-Assembled Nanostructure 2004

摘要:從書:Nanostructure science and technology 1 online resource (340 pages). Nanostructures refer to materials that have relevant dimensions on the nanometer length scales and reside in the mesoscopic regime between isolated atoms and molecules in bulk matter.  再讀一些...
展开
选择 引用 收藏

8、Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studie

摘要:Naturally occurring pentacyclic triterpenes (PT), a novel class of inhibitors against glycogen phosphorylase (GP), hold promise for the treatment of type-2 diabetes and other diseases with disorders in glycogen metabolism. To identify novel and more potent GP inhibitors, the receptor-based comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) approaches were performed to investigate the quantitative structure-activity relationships (QSAR) among 106 PT analogues. The validated models demonstrated that the elongated or bulky substitutions in C17 position and/or C2, C3 positions are favorable. Then based on the structural information extracted from these models, 56 derivatives were synthesized and biochemically tested in this study. The IC50 value of the most potent compound P50 was found to be 1.1μM.
展开
选择 引用 收藏

9、Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation

摘要:Research confirms that maternal ethanol (EtOH) exposure can induce physical and mental disorders in offspring, yet the effect of paternal ethanol exposure on offspring is unclear. Methylation alterations in imprinted genes may be related to the well-documented teratogenic effects of ethanol. Here, we report that ethanol (0, 1.1, 3.3 g/kg) was administered intragastrically to male mice and a behavioral study was performed on their F1 generation. Data show that F1 mice with fathers exposed to the highest dose of ethanol had delayed cognitive performance and increased anxiety and depression. A specific circling behavior was observed in the offspring of the paternally ethanol-exposed group. The degree of methylation and mRNA expression of H19, Peg3, Ndn and Snrpn were assessed in paternal sperm and in the cerebral cortices of each offspring. It did affect methylation in paternal sperm (H19 and Peg3) and in the offspring's cerebral cortices (CpG7 and CpG11 in Peg3 and Snrpn), but the level of mRNA expression has not changed. In the circling mice, the highest ethanol exposure increase in methylation (CpG 1, 2, 7 and 11) and decreases in mRNA of Peg3.Thus, chronic paternal ethanol exposure can affect the methylation of imprinted genes in sire sperm that may be passed on to offspring, giving rise to mental deficits.• We discovered behavioral abnormities in offspring of male parents exposed to ethanol. • Aberrant methylation was observed in the DNA methylation regions of imprinted genes in paternal sperm. • The same methylation and expression changes were also observed in the offsprings' cerebral cortices. • A possible explanation for the chronic ethanol-induced paternal germline epigenetic effects on offspring development.
展开
选择 引用 收藏

10、Preparation and RGB upconversion optic properties of transparent anti-counterfeiting film

11、Horizontal eyeball akinesia as an initial manifestation of CLIPPERS 2016

摘要:1 online resource Abstract: Background: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare chronic inflammatory disorder in the central nervous system (CNS), which is characterized by magnetic resonance imaging (MRI) appearance with punctate and curvilinear gadolinium enhancement "peppering" the pons. Lesions of CLIPPERS mainly involve the pons and the cerebellum. Adjacent structures such as the medulla and the midbrain may also be involved. It is proposed that CLIPPERS is an immune-mediated inflammatory condition characteristic of T-cell-predominant infiltrates and good responsiveness to corticosteroids. Methods and Results: We report a 46-year-old woman who presented with horizontal eyeball akinesia and gait ataxia with characteristic MRI features of CLIPPERS. The possible pathogenesis, clinical manifestations, imaging features, treatment, and prognosis of this peculiar disorder are summarized. Conclusion: This report contributes to the clinical understanding of CLIPPERS which may present with horizontal eyeball akinesia as an initial manifestation. The characteristic presentation of a subacute cerebellar and brainstem syndrome and pepper-like gadolinium enhancement was confirmed in this report. Long-term immunosuppressive treatment seems to be mandatory to sustain improvement. Azathioprine alone may be capable of maintaining remission.
展开
选择 引用 收藏

12、How to Obtain Reproducible Results for Lithium Sulfur Batteries?

13、High Energy Density Lithium-Sulfur Batteries: Challenges of Thick Sulfur Cathode

14、Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabete

选择 引用 收藏

15、Influence of surface pressure distribution of basic flow field on shape and performance of waverider 2015

16、An overview of research on waverider design methodology

摘要:A waverider is any supersonic or hypersonic lifting body that is characterized by an attached, or nearly attached, bow shock wave along its leading edge. As a waverider can possess a high lift-to-drag ratio as well as an ideal precompression surface of the inlet system, it has become one of the most promising designs for air-breathing hypersonic vehicles. This paper reviews and classifies waverider design methodologies developed by local and foreign scholars up until 2016. The design concept of a waverider can be summarized as follows: modeling of the basic flow field is used to design the waverider in the streamwise direction and the osculating theory is used to design the waverider in the spanwise direction.• Waverider design method by local and foreign scholars is reviewed and classified. • Modeling of basic flow field is used to design waverider in streamwise direction. • Osculating theory is used to design waverider in spanwise direction.
展开
选择 引用 收藏

17、Synchronized age-related gene expression changes across multiple tissues in human and the link to complex disease

选择 引用 收藏

18、Fighting for peace : narratives of Chinese forces on UN peacekeeping missions' frontline 2011

19、Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial

摘要:The effect of the α-glucosidase inhibitor acarbose on cardiovascular outcomes in patients with coronary heart disease and impaired glucose tolerance is unknown. We aimed to assess whether acarbose could reduce the frequency of cardiovascular events in Chinese patients with established coronary heart disease and impaired glucose tolerance, and whether the incidence of type 2 diabetes could be reduced. The Acarbose Cardiovascular Evaluation (ACE) trial was a randomised, double-blind, placebo-controlled, phase 4 trial, with patients recruited from 176 hospital outpatient clinics in China. Chinese patients with coronary heart disease and impaired glucose tolerance were randomly assigned (1:1), in blocks by site, by a centralised computer system to receive oral acarbose (50 mg three times a day) or matched placebo, which was added to standardised cardiovascular secondary prevention therapy. All study staff and patients were masked to treatment group allocation. The primary outcome was a five-point composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, hospital admission for unstable angina, and hospital admission for heart failure, analysed in the intention-to-treat population (all participants randomly assigned to treatment who provided written informed consent). The secondary outcomes were a three-point composite outcome (cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke), death from any cause, cardiovascular death, fatal or non-fatal myocardial infarction, fatal or non-fatal stroke, hospital admission for unstable angina, hospital admission for heart failure, development of diabetes, and development of impaired renal function. The safety population comprised all patients who received at least one dose of study medication. This trial is registered with ClinicalTrials.gov, number NCT00829660, and the International Standard Randomised Controlled Trial Number registry, number ISRCTN91899513. Between March 20, 2009, and Oct 23, 2015, 6522 patients were randomly assigned and included in the intention-to-treat population, 3272 assigned to acarbose and 3250 to placebo. Patients were followed up for a median of 5·0 years (IQR 3·4-6·0) in both groups. The primary five-point composite outcome occurred in 470 (14%; 3·33 per 100 person-years) of 3272 acarbose group participants and in 479 (15%; 3·41 per 100 person-years) of 3250 placebo group participants (hazard ratio 0·98; 95% CI 0·86-1·11, p=0·73). No significant differences were seen between treatment groups for the secondary three-point composite outcome, death from any cause, cardiovascular death, fatal or non-fatal myocardial infarction, fatal or non-fatal stroke, hospital admission for unstable angina, hospital admission for heart failure, or impaired renal function. Diabetes developed less frequently in the acarbose group (436 [13%] of 3272; 3·17 per 100 person-years) compared with the placebo group (513 [16%] of 3250; 3·84 per 100 person-years; rate ratio 0·82, 95% CI 0·71-0·94, p=0·005). Gastrointestinal disorders were the most common adverse event associated with drug discontinuation or dose changes (215 [7%] of 3263 patients in the acarbose group vs 150 [5%] of 3241 in the placebo group [p=0·0007]; safety population). Numbers of non-cardiovascular deaths (71 [2%] of 3272 vs 56 [2%] of 3250, p=0·19) and cancer deaths (ten [vs 12 [
展开
选择 引用 收藏

20、Long-life design and test technology of typical aircraft structure 2018

摘要:1 online resource This book addresses anti-fatigue manufacturing, analysis and test verification technologies for typical aircraft structures, including fastening holes, shot peening plates, different types of joints and wing boxes.  再讀一些...
展开
选择 引用 收藏