Goro Takada
共找到 9 条论著文献

1、Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese

2、A New Locus for a Dominant Form of Multinodular Goiter on 3q26.1-q26.3

3、Prolonged activation of the hypothalamus- pituitary-gonadal axis in a child with X-linked adrenal hypoplasia congenita

4、Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adrenal hypoplasia congenita

5、Case Report: Osteopontin expression in the liver with severe perisinusoidal fibrosis: Autopsy case of Down syndrome with transient myeloproliferative disorder

6、DOPPLER ECHOCARDIOGRAPHIC FINDINGS OF INDOMETHACIN-INDUCED OCCLUSION OF THE FETAL DUCTUS ARTERIOSUS

7、Letter to the Editor: Luteinizing hormone-releasing hormone analog treatment for a criminal sexual habit caused by male precocious puberty

8、Osteopontin expression in the liver with severe perisinusoidal fibrosis: Autopsy case of Down syndrome with transient myeloproliferative disorder OPN expression in liver fibrosi

9、Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

摘要:Genetic impairment was revealed in idiopathic cardiomyopathy and the responsible DNA locus was estimated. Mitochondrial DNA were amplified from autopsied cardiac specimens from three patients who died from hypertrophic or dilated cardiomyopathy by using polymerase chain reaction (PCR). By using two novel methods for PCR gene amplification, the pleioplasmic existence of multiple populations of differently deleted mitochondrial DNA in all specimens from the patients was confirmed. Mitochondrial DNA with a 7,436 bp deletion which commonly existed among the specimens was sequenced and the direct repeat at each edge of deletion was identified as (CATCAACAACCG) which was located in ATPase 6 gene and in the D-loop region. From our results mitochondrial DNA mutations could also be an important contributory factor to cardiomyopathy.
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