Goro Takada
共找到 15 条论著文献

1、Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese

2、Symptomatic Aortic Regurgitation after Blalock-Taussig Shunt in Tetralogy of Fallot with Bicuspid Aortic Valve

3、Changes in right ventricular volume in early human neonate

摘要:To evaluate changes in the right ventricular volume in early human neonates, twenty fullterm infants were examined at 2, 24 and 120 h of age by two-dimensional echocardiography. End-diastolic and end-systolic right ventricular volumes (RVEDV and RVESV, respectively) were calculated with a computer system based on the bi-plane Simpson's rule using the apical four chamber and parasternal short axis views. Then right ventricular stroke volume (RVSV), ejection fraction (RVEF), and the mean normalized systolic ejection rate were obtained. The inner diameter of the ductus arteriosus was also measured simultaneously. RVEDV increased significantly by 24 h of age, but remained constant thereafter. RVESV remained virtually unchanged from 2 to 120 h, resulting in a significant increase (36%) of RVSV at 24 h compared with that at 2 h. The mean normalized systolic ejection rate remained unchanged. There was a good correlation between RVEDV and RVSV (r=0.83). All ductus arteriosus except three narrow ones was closed by 24 h of age. In conclusion, at 24 h of age, the significantly increased RVEDV was closely related to the increased RVSV, which might be induced by increased volume load to the right ventricle because of the closure of the ductus arteriosus.
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4、DOPPLER ECHOCARDIOGRAPHIC FINDINGS OF INDOMETHACIN-INDUCED OCCLUSION OF THE FETAL DUCTUS ARTERIOSUS

5、Letter to the Editor: Luteinizing hormone-releasing hormone analog treatment for a criminal sexual habit caused by male precocious puberty

6、Osteopontin expression in the liver with severe perisinusoidal fibrosis: Autopsy case of Down syndrome with transient myeloproliferative disorder OPN expression in liver fibrosi

7、Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

摘要:Genetic impairment was revealed in idiopathic cardiomyopathy and the responsible DNA locus was estimated. Mitochondrial DNA were amplified from autopsied cardiac specimens from three patients who died from hypertrophic or dilated cardiomyopathy by using polymerase chain reaction (PCR). By using two novel methods for PCR gene amplification, the pleioplasmic existence of multiple populations of differently deleted mitochondrial DNA in all specimens from the patients was confirmed. Mitochondrial DNA with a 7,436 bp deletion which commonly existed among the specimens was sequenced and the direct repeat at each edge of deletion was identified as (CATCAACAACCG) which was located in ATPase 6 gene and in the D-loop region. From our results mitochondrial DNA mutations could also be an important contributory factor to cardiomyopathy.
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8、Role of age on transmitral flow velocity patterns in assessing left ventricular diastolic function in normal infants and children

9、Abnormal left ventricular diastolic filling patterns in small-for-gestational-age infant

摘要:Doppler transmitral flow velocity patterns in assessing left ventricular diastolic function in small-for-gestational-age infants have been poorly understood. The purpose of this study is to examine Doppler filling patterns in small-for-gestational-age infants ( n=13) and to compare them with those in age-matched appropriate-for-gestational-age infants ( n=29). We measured peak flow velocities of early diastole (peak E wave) and atrial contraction (peak A wave), ratio of peak E wave to peak A wave (peak E/A wave), velocity time integrals of E wave (VTIE wave) and A wave (VTIA wave), ratio of VTIE wave to VTIA wave (VTIE/A wave), first third filling fraction, peak filling rate normalized to stroke volume, and deceleration time. Mean gestational age and heart rate did not show a significant difference between the appropriate- and the small-for-gestational-age infants. The mean birth weight in the small-for-gestational-age infants was significantly lower than that in the appropriate-for-gestational-age infants (802±220 vs. 1184±260 g, P<0.01). In the small-for-gestational-age infants, the peak E wave, peak A wave, peak E/A wave, VTIE wave, first third filling fraction, and peak filling rate normalized to stroke volume were significantly lower than those in the age-matched appropriate-for- gestational-age infants (21.9±6.7 vs. 32.2±6.9 cm/s, 26.5±6.2 vs. 34.5±6.2 cm/s, 0.82±0.15 vs. 0.93±0.14, 1.88±0.45 vs. 2.39±0.51 cm, 0.36±0.04 vs. 0.41±0.04, 5.86±0.75 vs. 7.11±0.63/s, P<0.05, respectively). In the small and appropriate for gestational age infants, peak E wave, VTIE wave, and peak E/A increased significantly with increasing body weight. In the small-for-gestational-age infants, the slopes of regression lines between body weights and peak E wave and VTIE wave were significantly lower than those in the appropriate for gestational age infants, suggesting a significant reduction in E wave even when considering a difference in their body weight. This study suggests that the significant decreases in the early diastolic filling in the small-for-gestational-age infants may be related to the reduced left ventricular diastolic function.
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10、Effects of cardiac output on Doppler transmitral and transtricuspid flow velocity patterns in very low birth weight infant

11、Changes in Left Ventricular Diastolic Filling Patterns before and after the Closure of the Ductus Arteriosus in Very-Low-Birth Weight Infant

12、Prolonged activation of the hypothalamus- pituitary-gonadal axis in a child with X-linked adrenal hypoplasia congenita

13、Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adrenal hypoplasia congenita

14、Case Report: Osteopontin expression in the liver with severe perisinusoidal fibrosis: Autopsy case of Down syndrome with transient myeloproliferative disorder

15、A New Locus for a Dominant Form of Multinodular Goiter on 3q26.1-q26.3