共找到 229,976 条论著文献

1、Enhanced photocatalytic performance: a β-Bi2O3 thin film by nanoporous surface

摘要:Beta-Bi2O3 film photoanodes with different surface structures were prepared by oxidizing bismuth films. The physical properties were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM), UV-visible absorbance spectra and atomic force microscopy (AFM). XRD shows that all films are beta phase crystal structure except the thinnest 12 nm film. SEM and AFM characterizations indicate that a nanoporous surface structure is generated on the surface after the film is annealed for 3 h, while the films annealed for 1 h show a dense surface. The direct band gaps vary from 2.63 to 2.88 eV, with the film thickness decreasing from 500 to 12 nm. The nanoporous surface structure film exhibits better light harvesting ability and incident photon-to-electron conversion efficiency (IPCE) than the dense surface films. The IPCE (61% at 350 nm and 43% at 400 nm, 0.197 VNHE) is the highest ever reported. The photocurrent density reaches 0.45 mA cm−2 when illuminated with a bias of 1.23 VNHE in 0.5M Na2SO3.
展开
选择 引用 收藏

2、Snow-sourced bromine and its implications for polar tropospheric ozone

3、Study on the Influence ofRhizoma Zingiberison the Absorptive Profile of Aconite Alkaloids in the Rat Gut Sacs by Ultra Performance Liquid Chromatography-Mass Spectrometry

4、Extra-binomial variation approach for analysis of pooled DNA sequencing data

摘要:Motivation: The invention of next-generation sequencing technology has made it possible to study the rare variants that are more likely to pinpoint causal disease genes. To make such experiments financially viable, DNA samples from several subjects are often pooled before sequencing. This induces large between-pool variation which, together with other sources of experimental error, creates over-dispersed data. Statistical analysis of pooled sequencing data needs to appropriately model this additional variance to avoid inflating the false-positive rate. Results: We propose a new statistical method based on an extra-binomial model to address the over-dispersion and apply it to pooled case-control data. We demonstrate that our model provides a better fit to the data than either a standard binomial model or a traditional extra-binomial model proposed by Williams and can analyse both rare and common variants with lower or more variable pool depths compared to the other methods. Availability: Package 『extraBinomial』 is on http://cran.r-project.org/ Contact: chris.wallace{at}cimr.cam.ac.uk Supplementary information: Supplementary data are available at Bioinformatics Online.
展开
选择 引用 收藏

5、Piezoelectric diaphragm as a high performance biosensor platform

6、A software radio platform based on ARM and FPGA

摘要:The rapid rise in computational performance offered by computer systems has greatly increased the number of practical software radio applications. A scheme presented in this paper is a software radio platform based on ARM and FPGA. FPGA works as the coprocessor together with the ARM, which serves as the core processor. ARM is used for digital signal processing and real-time data transmission, and FPGA is used for synchronous timing control and serial-parallel conversion. A SPI driver for real-time data transmission between ARM and FPGA under ARM-Linux system is provided. By adopting modular design, the software radio platform is capable of implementing wireless communication functions and satisfies the requirements of real-time signal processing platform for high security and broad applicability.
展开
选择 引用 收藏

7、Quantitative Assessment of the Influence of Rhizoma Zingiberis on the Level of Aconitine in Rat Gut Sacs and Qualitative Analysis of the Major Influencing Components of Rhizoma Zingiberis on Aconitine Using UPLC/MS

8、Hierarchical contour matching in medical image

9、Association of Matrix Metalloproteinase-3 -1171(5A>6A) Polymorphism with Cancer Risk: A Meta-Analysis of 41 Studie

摘要:Background and Objective Evidence has shown that matrix metalloproteinases-3 (MMP3) is important for cancer progression. Recent studies about the association between the -1171(5A>6A) polymorphism in MMP3 promoter region and cancer risk have yielded conflicting results. Methodology/Principal Findings We performed a meta-analysis of 41 studies including 11112 cases and 11091 controls to determine whether the -1171(5A>6A) polymorphism of MMP3 was associated with cancer risk. We assessed the strength of association and performed sub-group analyses by cancer types, ethnicity, smoking status, genotyping method, source of controls and sample size. The pooled results revealed that no significant association of the -1171(5A>6A) polymorphism with overall cancer risk in any of four models. Further sub-group analysis revealed that individuals with the 6A allele had lower risk of gastrointestinal cancer in two models: heterozygote comparison (6A/5A vs. 5A/5A: OR = 0.74, 95%CI: 0.60—0.91; I2 = 1.9%), and dominant model (6A/6A+6A/5A vs. 5A/5A: OR = 0.77, 95%CI: 0.64—0.94; I2 = 29.0%). Additionally, the associations were significant in Asian populations for three models: homozygote comparison (6A/6A vs. 5A/5A, OR = 0.68, 95%CI: 0.52—0.90; I2 = 26.7%), heterozygote comparison (6A/5A vs. 5A/5A: OR = 0.75, 95%CI: 0.58—0.98; I2 = 0.0%), and dominant model (6A/6A+6A/5A vs. 5A/5A: OR = 0.69, 95%CI: 0.54—0.88; I2 = 0.5%). It was noteworthy that we had a contrary finding in non-smokers: the variant 6A/6A homozygote might statistically increase cancer risk compared with 6A/5A+5A/5A genotype (OR = 1.92, 95%CI: 1.25—2.96; I2 = 72.7%). Conclusion This meta-analysis suggests that the -1171(5A>6A) polymorphism in MMP3 promoter region is not associated with overall cancer risk, but it may contribute to decreased cancer risk in Asian population when compared with Caucasian population and significantly reduce the risk of gastrointestinal cancer.
展开
选择 引用 收藏

10、The Exploration of Social Media Marketing Strategies of Destination Marketing Organizations in China

摘要:The popularity of social media (e.g., social networking sites, micro-blogs websites) presents both opportunities and challenges for destination marketing organizations (DMOs). DMOs need to develop social media marketing strategies to improve their marketing effectiveness and meet the expectations of their stakeholders. Contextualized in Mainland China, this study explores DMOs』 social media marketing strategies and outcomes by investigating their adoption of social media channels and their activities on the channels. It describes China’s unique social media landscape and then identifies and evaluates a variety of social media marketing strategies that have been adopted by overseas DMOs.
展开
选择 引用 收藏

11、Bi-Objective Flexible Job-Shop Scheduling Problem Considering Energy Consumption under Stochastic Processing Time

摘要:This paper presents a novel method on the optimization of bi-objective Flexible Job-shop Scheduling Problem (FJSP) under stochastic processing times. The robust counterpart model and the Non-dominated Sorting Genetic Algorithm II (NSGA-II) are used to solve the bi-objective FJSP with consideration of the completion time and the total energy consumption under stochastic processing times. The case study on GM Corporation verifies that the NSGA-II used in this paper is effective and has advantages to solve the proposed model comparing with HPSO and PSO+SA. The idea and method of the paper can be generalized widely in the manufacturing industry, because it can reduce the energy consumption of the energy-intensive manufacturing enterprise with less investment when the new approach is applied in existing systems.
展开
选择 引用 收藏

12、Intelligent distributed computing XII 2018

13、Study on the Metabolic Characteristics of Aconite Alkaloids in the Extract of Radix aconiti under Intestinal Bacteria of Rat by UPLC/MSn Technique

摘要:The extract of Radix aconiti was incubated with rat intestinal bacteria in vitro. Further, aconitine and hypaconitine standard were incubated at the same condition as the extract of Radix aconiti, respectively. Ultra Performance Liquid Chromatography/Multi-Mass Spectrometry (UPLC/MSn) was used for detecting and identifying all the aconite alkaloids. Results showed that there were four metabolites which were identified as 8-butyryl-14-benzoylmesa-conine (m/z660), 8-propionyl-14-benzoylaconine (m/z660), 8-butyryl-14-benzoylaconine (m/z 674) and 8-valeryl-14-benzoylmesaconine (m/z674) in the metabolized sample of the extract of Radix aconiti. The relative area ratio of them presented increasing trend during 6 d. On the basis of all results, we could concluded that substitution at N atom mainly influenced the metabolizing rate of diester-diterpenoid alkaloids (DDAs), C-8 substitute was active metabolized site, intestinal bacterial metabolites of the aconite alkaloids in the extract of Radix aconiti were mainly the substitute with propionyl group, butyl group or valeryl group at C-8. This paper illustrated holistic metabolizing profile of the extract of Radix aconiti in vitro and possible metabolizing reaction type of main DDAs, which could provide reference for finding out potential bioactive components in the extract and the prescription of Chinese Medicine.This paper illustrated holistic metabolizing profile of the extract of Radix aconiti in vitro and possible metabolizing reaction type of main DDAs, which could provide reference for finding out potential bioactive components in the extract and the prescription of Chinese Medicine.
展开
选择 引用 收藏

14、Rice responses to single application of coated urea on yield, dry matter accumulation, and nitrogen uptake in Southern China

15、Mutational analysis on gastric, duodenal, bone, and mediastinal lymph node metastases and blood from a case of primary lung adenocarcinoma

摘要:Mutational analysis on gastric, duodenal, bone, and mediastinal lymph node metastases and blood from a case of primary lung adenocarcinoma Xin Yang, Rui Chen, Chen Wu, Weiqing Zhao, Mei Ji Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China Abstract: Rapid metastasis contributes significantly to the high mortality rates in lung adenocarcinoma. The present study reports a rare case of primary lung adenocarcinoma with concomitant gastric, duodenal, bone, and mediastinal lymph node metastases. A large gene panel based on the next-generation sequencing was used to detect gene mutations in different metastatic sites and blood. The results showed that the gene mutation spectrums among different metastatic foci were roughly similar. The mutation abundance was highest in mediastinal lymph nodes. Unique mutation sites were detected only in mediastinal lymph nodes, bone, and gastric metastatic foci. Despite partial heterogeneity, there are currently no applicable targeted drugs to adopt. In addition, tumor mutation burden (TMB) showed that blood, gastric, bone, and mediastinal lymph node metastases were all TMB-High, while the duodenal metastasis was TMB-Low. This study is the first to report a rare case of newly diagnosed lung adenocarcinoma with concomitant gastrointestinal metastases and to perform mutation analyses on all metastatic foci. Large sample sizes with similar cases are required to gain deeper insights. Keywords: lung adenocarcinoma, gastric metastasis, duodenal metastasis, TMB
展开
选择 引用 收藏

16、Serum Metabonomics Analysis of Fuzi Lizhong Decoction for the Treatment of Splenasthenic Syndrome

摘要:Fuzi lizhong decoction (FLD) derives from an ancient Chinese Pharmacopoeia: San Yin Ji Bing Zheng Fang Lun, composed of equal amounts of Aconitum carmichaeli Debeaux (ACD); Zingiber officinale Roscoe (ZOR); Glycyrrhiza uralensis Fisch. (GUF); Atractylodes macrocephala Koidz. (AMK); and Codonopsis pilosula Franch. (CPF). Its pill has been used for the treatment of gastrointestinal disorders for years. The objective of this study was to clarify the curative effect of FLD on splenasthenic syndrome and to identify biomarkers upon which FLD acts as a therapeutic agent based on a serum metabonomics analysis. Serum samples from a blank group (BG), a model group (MG), and a treatment group (TG) of rats were analyzed using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS). Then, both the endogenous metabolites and metabolic pathways in the MG samples versus the BG samples were investigated. A partial least squares discriminant analysis (PLS-DA) was used to separate MG from BG and to filter the different endogenous metabolites between the two groups. Furthermore, analysis of variance (ANOVA) was used to select potential biomarkers that significantly differed in MG compared with those in BG to evaluate their callback situation in TG. Compound identification was performed based on retention time, accurate mass weight, and MS/MS spectra by searching online databases and references. The results showed that 166 of 1189 total detected ions were different between MG and BG according to the variable importance plot (VIP) values (>1.5) obtained through partial least squares discriminate analysis (PLS-DA), 62 of which were detected in positive mode and 104 of which were detected in negative mode. Fifteen compounds, including L-palmitoylcarnitine, 11Z-octadecenylcarnitine, LysoPC(14:0), LysoPC(16:1(9Z)), LysoPC(P-18:0), LysoPE(20:0/0:0), LysoPC(18:2(9Z,12Z)), LysoPC(18:1(9Z)), LysoPC(18:0), LysoPC(20:2(11Z,14Z)), LysoPC(20:0), uric acid, 2-phenylethanolglucuronide, LysoPC(15:0), and LysoPC(16:0), were identified and considered biomarkers of splenasthenic syndrome. Among them, LysoPC(15:0), LysoPC(16:0), L-palmitoylcarnitine, 11Z-octadecenylcarnitine, LysoPC(16:1(9Z)), and LysoPC(P-18:0) were retrieved after rats were cured with FLD in TG, and the related pathways involving fatty acid degradation and glycerophospholipid metabolism were identified. This experiment confirmed that FLD may treat splenasthenic syndrome by improving fatty acid degradation and glycerophospholipid metabolism and is expected to be developed as a beneficial pharmaceutical for the spleen.
展开
选择 引用 收藏

17、Learning Optimized Local Difference Binaries for Scalable Augmented Reality on Mobile Device

摘要:The efficiency, robustness and distinctiveness of a feature descriptor are critical to the user experience and scalability of a mobile augmented reality (AR) system. However, existing descriptors are either too computationally expensive to achieve real-time performance on a mobile device such as a smartphone or tablet, or not sufficiently robust and distinctive to identify correct matches from a large database. As a result, current mobile AR systems still only have limited capabilities, which greatly restrict their deployment in practice. In this paper, we propose a highly efficient, robust and distinctive binary descriptor, called Learning-based Local Difference Binary (LLDB). LLDB directly computes a binary string for an image patch using simple intensity and gradient difference tests on pairwise grid cells within the patch. To select an optimized set of grid cell pairs, we densely sample grid cells from an image patch and then leverage a modified AdaBoost algorithm to automatically extract a small set of critical ones with the goal of maximizing the Hamming distance between mismatches while minimizing it between matches. Experimental results demonstrate that LLDB is extremely fast to compute and to match against a large database due to its high robustness and distinctiveness. Compared to the state-of-the-art binary descriptors, primarily designed for speed, LLDB has similar efficiency for descriptor construction, while achieving a greater accuracy and faster matching speed when matching over a large database with 2.3M descriptors on mobile devices.
展开
选择 引用 收藏

18、A survey of liveness detection methods for face biometric system

19、The efficacy and safety of sodium hyaluronate injection (Adant®) in treating degenerative osteoarthritis: a multi-center, randomized, double-blind, positive-drug parallel-controlled and non-inferiority clinical study

摘要:Objective: To compare the efficacy and safety of two different sodium hyaluronate drugs in treating degenerative osteoarthritis (OA) of the knee.Method: This randomized, multi-center, double-blind, positive-drug, parallel-controlled study included 229 patients aged ≥ 45 years who were clinically diagnosed with degenerative OA of the knee. The patients were randomly assigned to receive for 5 consecutive weeks a once-weekly intra-articular injection of the investigational drug Adant®, which is manufactured by fermentation, or the control drug Artz®, which is manufactured by extraction of cockscomb. The follow-up examinations were conducted 1, 2, 3, 4 and 6 weeks after the first injection. The primary efficacy parameter was the decrease in the visual analog scale (VAS) scores of pain on movement caused by load-bearing, and the secondary efficacy parameter was the decrease in the Lequesne index.Results: The intra-articular injections of Adant® and Artz® produced a significant reduction in the VAS scores for pain on movement (50.4 and 50.3 mm, respectively) and in the Lequesne index. There were no significant differences in efficacy and safety between the two drugs and non-inferiority in VAS score decreases was confirmed.Conclusion: The results of this study show that both Adant® and Artz® are effective for the treatment of OA and that there were no statistical differences between them in the VAS scores of pain on movement, Lequesne index or safety during the observation period with short-time follow up.
展开
选择 引用 收藏

20、STUDY OF REGIONAL ECONOMIC BENEFIT MODEL OF TRANSPORTATION SYSTEM PROJECTS

摘要:The regional economic benefit of a communications and transportation construction project is an important part of its economic benefit. Nowadays qualitative analysis is still the main method. This paper proposes a new method and model to study the regional economic benefit with System Engineering Theory and Input-Output Method. Also the Beijing-Tianjin area is taken as an example, the regional economic benefits of the Jin-jin-tang expressway and the third Jing-jing railways projects are carefully calculated and discussed, and some effective ways and means are drawn out.
展开
选择 引用 收藏

结果集较大,只显示前20,000条数据。修改检索词或筛选条件获取更精准结果。