共找到 185,184 条论著文献

41、On the share price impact of voluntary disclosure when accounting fails : evidence from the UK biotechnology sector 2003

42、The Cadbury Report : its effects on UK board structure and managerial entrenchment 2002

43、Fundamentals of accounting 2008

44、B-17s over Berlin : personal stories from the 95th Bomb Group (H) 1995

45、Experiences and challenges in the development of the Chinese capital market 2015

摘要:xiii, 203 pages ; 23 cm The focus of the global economy has increasingly shifted toward China and emerging countries. However, despite their high growth prospects, emerging economies often lack the sound capital market and corporate governance systems necessary to promote the efficient allocation of financial resources to maintain the confidence of capital providers.  再讀一些...
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46、Corporate governance : an international perspective 2008

摘要:從書:International journal of managerial finance, v. 4, no. 4. 1 online resource.
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47、International Journal of Managerial Finance 2008

摘要:1 online resource (97 pages) The papers in this e-book demonstrate the importance of considering the effectiveness of corporate governance in the context of the organisational environment. Building on a range of research perspectives and theoretical approaches they help to explain wh.
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48、Shareholder wealth effects of CEO departures : evidence from the UK 2000

摘要:從書:Discussion paper (University of Bristol. Department of Economics), no. 00/498. 42 pages ; 21 cm.
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49、Voluntary disclosure and its impact on share prices : evidence from the UK biotechnology sector 2007

50、Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

51、G-Protein-gated Inwardly-Rectifying K+ Channels and Large-conductance Calcium-Activated K+ Channels Are Involved in C-Type Natriuretic Peptide-Mediated Vasodilation in Human Arterie

52、Wnt5a regulates the cell proliferation and adipogenesis via MAPK-independent pathway in early stage of obesity

摘要:The early stage of obesity is an important stage in the development of obesity. However, there are few studies which explored the property or changes in obesity at early stage especially involving Wnt5a. The associated gene expression of Wnt5a on cell regeneration and the effect of Wnt5a on rat adipose-derived stem cell (rASC) proliferation and adipogenesis need additional study. Here, we investigated the changes in obesity at early stage and how Wnt5a regulates rASC regeneration, proliferation, and adipogenesis. Our data revealed that obesity at early stage measured by Lee index presented a state with impaired adipogenesis and more infiltrated inflammatory cells but without significant changes in adipocyte sizes and inflammatory factors. The process might be associated with anti-canonical Wnt pathway and a reciprocal Wnt5a/JNK pathway. Besides the gene expression of Wnt5a decreased from cell passage 1 to passage 3. The cell proliferation was regulated by increasing dose of Wnt5a with the maximal effect at 50 ng/mL and 50 ng/mL Wnt5a suppressed adipogenic differentiation at middle-late stage of adipogenesis via anti-β-catenin and a mitogen-activated protein kinase (MAPK) signaling-independent manner. Accordingly, the research helps to gain further insights into the early stage of obesity and its associated changes on a cellular and molecular level.
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53、Bio-inspired synthesis of molecularly imprinted nanocomposite membrane for selective recognition and separation of artemisinin

摘要:Inspired from the highly bioadhesive performance of mussel protein, a simple, yet efficient synthetic method for efficiently imprinting of Artemisinin (Ars) was developed to prepare the bio-inspired molecularly imprinted membranes (MIMs) via atom transfer radical polymerization (ATRP). In this work, attributed to the unique properties of polydopamine (pDA) modified layers and ATRP technology, the uniform recognition sites for efficiently selective extraction of the Ars with high stability could be obtained on the MIMs surfaces. In addition, the maximum adsorption capacity of the MIMs is 158.85 mg g−1 by the Langmuir isotherm model, which is remarkable higher than NIMs. Additionally, because of the formation of the uniform specific recognition cavities on membrane surfaces, the as-prepared MIMs exhibited a rapid adsorption dynamics and well-fitted for the pseudo-second-order rate equation, also, possessed an excellent per-selectivity performance (βartemether/Ars values is 0.18) of template molecule, which clearly demonstrated the potential value of this method in the selective separation and purification of Ars. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43405.
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54、Different thermal processing effects on peanut allergenicity Different thermal processing effects on peanut allergenicity

55、Bioinspired synthesis of SiO ₂ /pDA-based nanocomposite-imprinted membranes with sol–gel imprinted layers for selective adsorption and separation application

56、Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumor

摘要:Mutations or aberrant upregulation of EZH2 occur frequently in human cancers, yet clinical benefits of EZH2 inhibitor (EZH2i) remain unsatisfactory and limited to certain hematological malignancies. We profile global posttranslational histone modification changes across a large panel of cancer cell lines with various sensitivities to EZH2i. We report here oncogenic transcriptional reprogramming mediated by MLL1’s interaction with the p300/CBP complex, which directs H3K27me loss to reciprocal H3K27ac gain and restricts EZH2i response. Concurrent inhibition of H3K27me and H3K27ac results in transcriptional repression and MAPK pathway dependency in cancer subsets. In preclinical models encompassing a broad spectrum of EZH2-aberrant solid tumors, a combination of EZH2 and BRD4 inhibitors, or a triple-combination including MAPK inhibition display robust efficacy with very tolerable toxicity. Our results suggest an attractive precision treatment strategy for EZH2-aberrant tumors on the basis of tumor-intrinsic MLL1 expression and concurrent inhibition of epigenetic crosstalk and feedback MAPK activation.Display Omitted• Epigenetic signature profiling in ∼100 tumor lines with different EZH2i sensitivities • MLL1-p300/CBP-mediated H3K27ac gain and oncogenic reprogramming limit EZH2i response • H3K27ac co-inhibition improves EZH2i efficacy but activates MAPK in some cancers • MLL1 level and inhibiting feedback MAPK activation expand EZH2i utility and precisionEpigenetic crosstalk targeting together with MLL1-based stratification and inhibiting feedback MAPK activation expand EZH2 inhibitors』 therapeutic utility and efficacy in patient-derived solid tumor models.
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57、Loss of Core 1-derivedO-Glycans Decreases Breast Cancer Development in Mice

58、Speciation, adsorption and determination of chromium(III) and chromium(VI) on a mesoporous surface imprinted polymer adsorbent by combining inductively coupled plasma atomic emission spectrometry and UV spectrophotometry Other Technique

59、Identification of a cellularly active SIRT6 allosteric activator

60、Wnt5a regulates the cell proliferation and adipogenesis via MAPK-independent pathway in early stage of obesity Wnt5a involves proliferation and adipogenesi

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